Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism

The LIM domain only 4 (LMO4) protein is expressed in the hypothalamus, but its function there is not known. Using mice with LMO4 ablated in postnatal glutamatergic neurons, including most neurons of the paraventricular (PVN) and ventromedial (VMH) hypothalamic nuclei where LMO4 is expressed, we aske...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2012-03, Vol.69 (5), p.819-828
Hauptverfasser:	Zhou, Xun, Gomez-Smith, Mariana, Qin, Zhaohong, Duquette, Philippe M., Cardenas-Blanco, Arturo, Rai, Punarpreet S., Harper, Mary-Ellen, Tsai, Eve C., Anisman, Hymie, Chen, Hsiao-Huei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adipocytes Adipose tissue Adipose Tissue - metabolism Animals Biochemistry Biomedical and Life Sciences Biomedicine Body fat Cell Biology Energy expenditure Energy Metabolism Fat metabolism Feeding Food intake Glutamatergic transmission Homeostasis Hypothalamus Hypothalamus (ventromedial) Janus Kinases - metabolism Leptin Leptin - metabolism Life Sciences LIM Domain Proteins - deficiency LIM Domain Proteins - genetics LIM Domain Proteins - metabolism Lipid Metabolism Male Metabolism Mice Mice, Knockout Neuromodulation Neurons Neurons - metabolism Obesity - metabolism Obesity - physiopathology Peptide hormones Research Article Signal Transduction Stat3 protein STAT3 Transcription Factor - metabolism Thermogenesis Ventromedial Hypothalamic Nucleus - metabolism
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