Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61

The Hedgehog (Hh) pathway is well known for its involvement in angiogenesis and vasculogenesis during ontogeny. The ligand, Sonic Hh (SHH), has an important role in vascular formation during development. However, SHH expression is upregulated on tumor cells and can impact the tumor microenvironment....

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Veröffentlicht in:	Oncogene 2012-07, Vol.31 (28), p.3370-3380
Hauptverfasser:	Harris, L G, Pannell, L K, Singh, S, Samant, R S, Shevde, L A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Autocrine Communication - genetics Autocrine signalling Breast cancer Breast Neoplasms - blood supply Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell activation Cell Biology Cell Line, Tumor Cell Transformation, Neoplastic Cellular signal transduction CYR61 protein Cysteine-Rich Protein 61 - genetics Development Development and progression Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Female Gene Expression Regulation, Neoplastic Genetic aspects Hedgehog protein Hedgehog Proteins - metabolism Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Metastases Metastasis Mice Microenvironments Neoplasm Metastasis Neovascularization Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Oncology Ontogeny original-article Paracrine Communication - genetics Paracrine signalling Physiological aspects Prognosis Signal Transduction Transcription activation Transcription factors Transcription, Genetic Tumor cells Tumor microenvironment Tumors Up-Regulation Vascular endothelial growth factor Xenografts
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