2-Acetamino-1,2-dideoxynojirimycin—lysine hybrids as hexosaminidase inhibitors
Cyclisation by double reductive amination of 2-acetamino-2-deoxy- d- xylo-hexos-5-ulose with N-2 protected l-lysine derivatives provided 2-acetamino-1,2-dideoxynojirimycin derivatives without any observable epimer formation at C-5. Modifications on the lysine moiety gave access to lipophilic derivat...
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| Veröffentlicht in: | Tetrahedron: asymmetry 2009-05, Vol.20 (6), p.832-835 |
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| container_title | Tetrahedron: asymmetry |
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| creator | Steiner, Andreas J. Schitter, Georg Stütz, Arnold E. Wrodnigg, Tanja M. Tarling, Chris A. Withers, Stephen G. Mahuran, Don J. Tropak, Michael B. |
| description | Cyclisation by double reductive amination of 2-acetamino-2-deoxy-
d-
xylo-hexos-5-ulose with
N-2 protected
l-lysine derivatives provided 2-acetamino-1,2-dideoxynojirimycin derivatives without any observable epimer formation at C-5. Modifications on the lysine moiety gave access to lipophilic derivatives that exhibited improved hexosaminidase inhibitory activities. |
| doi_str_mv | 10.1016/j.tetasy.2009.02.015 |
| format | Article |
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| ispartof | Tetrahedron: asymmetry, 2009-05, Vol.20 (6), p.832-835 |
| issn | 0957-4166 1362-511X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3276585 |
| source | Elsevier ScienceDirect Journals |
| title | 2-Acetamino-1,2-dideoxynojirimycin—lysine hybrids as hexosaminidase inhibitors |
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