MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells

Although microRNA-21 (miR-21) is emerging as an oncogene and has been shown to target several tumor suppressor genes, including programmed cell death 4 (PDCD4), its precise mechanism of action on cancer stem cells (CSCs) is unclear. Herein, we report that FOLFOX-resistant HCT-116 and HT-29 cells tha...

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Veröffentlicht in:	Carcinogenesis (New York) 2012-01, Vol.33 (1), p.68-76
Hauptverfasser:	Yu, Yingjie, Kanwar, Shailender S., Patel, Bhaumik B., Oh, Phil-Sun, Nautiyal, Jyoti, Sarkar, Fazlul H., Majumdar, Adhip P.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis Regulatory Proteins - physiology beta Catenin - physiology Biological and medical sciences Biology, Genetics and Epigenetics Carcinogenesis, carcinogens and anticarcinogens Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Down-Regulation Drug Resistance, Neoplasm Gastroenterology. Liver. Pancreas. Abdomen HCT116 Cells HT29 Cells Humans Medical sciences MicroRNAs - physiology Neoplastic Stem Cells - pathology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - physiology Receptors, Transforming Growth Factor beta - antagonists & inhibitors Receptors, Transforming Growth Factor beta - physiology RNA-Binding Proteins - physiology Signal Transduction Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Wnt Signaling Pathway
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