Occluding the Mannose Moieties on Human Immunodeficiency Virus Type 1 gp120 with Griffithsin Improves the Antibody Responses to Both Proteins in Mice

To assess the influence of mannosylated glycans on the immunogenicity of human immunodeficiency virus type 1 (HIV-1) Env proteins, we immunized mice with monomeric gp120 in the presence and absence of the mannose-binding protein, griffithsin (GRFT). For comparison, other groups of mice received the...

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Veröffentlicht in:	AIDS research and human retroviruses 2012-02, Vol.28 (2), p.206-214
Hauptverfasser:	BANERJEE, Kaustuv, MICHAEL, Elizabeth, EGGINK, Dirk, MONTFORT, Thijs Van, LASNIK, Amanda B, PALMER, Kenneth E, SANDERS, Rogier W, MOORE, John P, JOHAN KLASSE, Per
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - immunology AIDS Vaccines - pharmacology AIDS/HIV Algal Proteins - pharmacology Animals Antibody Formation - immunology Biological and medical sciences Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology HIV Antibodies - immunology HIV Envelope Protein gp120 - immunology HIV-1 - drug effects HIV-1 - immunology Human immunodeficiency virus 1 Human viral diseases Infectious diseases Lectins - pharmacology Mannose - metabolism Mannose-Binding Lectin - pharmacology Medical sciences Mice Mice, Inbred C57BL Microbiology Miscellaneous Plant Lectins Retrovirus Vaccines Viral diseases Virology
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