Activation of P-TEFb at Sites of Dual HIV/TB Infection, and Inhibition of MTB-Induced HIV Transcriptional Activation by the Inhibitor of CDK9, Indirubin-3'-Monoxime

At sites of Mycobacterium tuberculosis (MTB) infection, HIV-1 replication is increased during tuberculosis (TB). Here we investigated the role of positive transcription elongation factor (P-TEFb), comprised of CycT1 and CDK9, as the cellular cofactor of HIV-1 Tat protein in transcriptional activatio...

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Veröffentlicht in:	AIDS research and human retroviruses 2012-02, Vol.28 (2), p.182-187
Hauptverfasser:	TOOSSI, Zahra, MIANDA WU, HIRSCH, Christina S, MAYANJA-KIZZA, Harriet, BASEKE, Joy, AUNG, Htin, CANADAY, David H, FUJINAGA, Koh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blotting, Western Coinfection Cyclin T - drug effects Female Fundamental and applied biological sciences. Psychology HIV Infections - drug therapy HIV Infections - genetics HIV Infections - metabolism HIV-1 - drug effects HIV-1 - physiology Human viral diseases Humans Indoles - pharmacokinetics Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - metabolism Oximes - pharmacokinetics Pathogenesis Positive Transcriptional Elongation Factor B - drug effects Positive Transcriptional Elongation Factor B - genetics Positive Transcriptional Elongation Factor B - metabolism Transcriptional Activation - drug effects Tuberculosis - drug therapy Tuberculosis - genetics Tuberculosis - metabolism Uganda - epidemiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology Virus Replication - drug effects
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