VEGFA Family Isoforms Regulate Spermatogonial Stem Cell Homeostasis in Vivo

The objective of the present study was to investigate vascular endothelial growth factor A (VEGFA) isoform regulation of cell fate decisions of spermatogonial stem cells (SSC) in vivo. The expression pattern and cell-specific distribution of VEGF isoforms, receptors, and coreceptors during testis de...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2012-02, Vol.153 (2), p.887-900
Hauptverfasser:	Caires, Kyle C, de Avila, Jeanene M, Cupp, Andrea S, McLean, Derek J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Animals, Newborn Biological activity Biological and medical sciences Biological effects Cell activation Cell differentiation Cell fate Cell self-renewal Decisions Differentiation Fundamental and applied biological sciences. Psychology Gene expression Growth factors Homeostasis Immunoglobulin G In vivo methods and tests Isoforms Male Mice Mice, Inbred C57BL Neonates Organ Size Phosphorylation Populations Postpartum period Protein Isoforms Quorum sensing Real-Time Polymerase Chain Reaction Receptor mechanisms Receptors Receptors, Vascular Endothelial Growth Factor - genetics Receptors, Vascular Endothelial Growth Factor - metabolism Reproduction-Development Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Spermatogonia Spermatogonia - drug effects Spermatogonia - physiology Stem Cell Transplantation Stem cells Testis - anatomy & histology Testis - drug effects Testis - growth & development Testis - metabolism Transplantation Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - pharmacology Vertebrates: endocrinology
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