Adrenal Cell Aldosterone Production Is Stimulated by Very-Low-Density Lipoprotein (VLDL)

Very low-density lipoproteins (VLDL) are a class of large lipoprotein synthesized in the liver. The key function of VLDL, in vivo, is to carry triglyceride from the liver to adipose tissue. As a steroidogenic organ, the adrenal gland mainly uses lipoproteins as sources of cholesterol. Although VLDL...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2012-02, Vol.153 (2), p.721-731
Hauptverfasser:	Xing, Yewei, Rainey, William E, Apolzan, John W, Francone, Omar L, Harris, Ruth B. S, Bollag, Wendy B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adrenal Cortex - cytology Adrenal Cortex - drug effects Adrenal Cortex - metabolism Adrenal glands Adrenocorticotropic hormone Aldosterone Aldosterone - biosynthesis Aldosterone synthase Angiotensin Angiotensin II Animals Biological and medical sciences Calcium Calcium - metabolism Calcium signalling Cattle Cell culture Cell Line Cells, Cultured Cholesterol Colforsin - pharmacology Cytochrome P-450 CYP11B2 - genetics Cytochrome P-450 CYP11B2 - metabolism Density Forskolin Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Enzymologic - physiology Glucocorticoids-CRH-ACTH-Adrenal Humans In vivo methods and tests Lipoproteins Lipoproteins (very low density) Lipoproteins, VLDL - pharmacology Liver Male Nifedipine Phosphoproteins - genetics Phosphoproteins - metabolism Rats Rats, Sprague-Dawley Receptor mechanisms RNA, Messenger - genetics RNA, Messenger - metabolism Signal transduction Signal Transduction - physiology Steroidogenesis Sucrose Synthesis Triglycerides Vertebrates: endocrinology Zona Glomerulosa - cytology Zona Glomerulosa - drug effects Zona Glomerulosa - metabolism
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