p53 serves as a host antiviral factor that enhances innate and adaptive immune responses to influenza A virus

Several direct target genes of the p53 tumor suppressor have been identified within pathways involved in viral sensing, cytokine production, and inflammation, suggesting a potential role of p53 in antiviral immunity. The increasing need to identify immune factors to devise host-targeted therapies ag...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-12, Vol.187 (12), p.6428-6436
Hauptverfasser:	Muñoz-Fontela, César, Pazos, Michael, Delgado, Igotz, Murk, William, Mungamuri, Sathish Kumar, Lee, Sam W, García-Sastre, Adolfo, Moran, Thomas M, Aaronson, Stuart A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - genetics Animals CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Gene Expression Regulation, Viral - immunology Immunity, Innate - genetics Influenza A virus Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H3N2 Subtype - immunology Male Mice Mice, 129 Strain Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - metabolism Orthomyxoviridae Infections - pathology Pneumonia, Viral - immunology Pneumonia, Viral - metabolism Pneumonia, Viral - pathology Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - physiology Viral Regulatory and Accessory Proteins - deficiency Viral Regulatory and Accessory Proteins - genetics Viral Regulatory and Accessory Proteins - physiology
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