Human immunoglobulin heavy chain genes: evolutionary comparisons of Cμ, Cδ and Cγ genes and associated switch sequences

Human immunoglobulin heavy chain constant region genes have been characterised in isolated clones. The human Cμ gene comprises discrete domains for Cμ1, Cμ2, Cμ3 and Cμ4 + tp separated by short intervening sequences. The Cδ gene has been located about 5 kb downstream of Cμ4. Furthermore, the coding...

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Veröffentlicht in:	Nucleic acids research 1981-09, Vol.9 (18), p.4509-4524
Hauptverfasser:	Rabbitts, T.H., Forster, A., Milstein, Celia P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Biological Evolution Cloning, Molecular DNA, Recombinant - metabolism Escherichia coli - genetics Genes Humans Immunoglobulin Constant Regions - genetics Immunoglobulin Heavy Chains - genetics Nucleic Acid Hybridization
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