Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites

An organism's genome sequence serves as a blueprint for the proteins and regulatory RNAs essential for cellular function. The genome also harbors cis-acting non-coding sequences that control gene expression and are essential to coordinate regulatory programs during embryonic development. Howeve...

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Veröffentlicht in:	Developmental biology 2011-09, Vol.357 (2), p.450-462
Hauptverfasser:	Aday, Aaron W., Zhu, Lihua Julie, Lakshmanan, Abirami, Wang, Jie, Lawson, Nathan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites ChIP-Seq chromatin Conserved Sequence - genetics Danio rerio DNA DNA, Intergenic - genetics Embryo, Nonmammalian - metabolism embryogenesis Enhancer enhancer elements Enhancer Elements, Genetic - genetics Freshwater gene expression Gene Expression Profiling Gene Expression Regulation, Developmental genes Genome - genetics high-throughput nucleotide sequencing Histone modification histones Histones - metabolism lysine Lysine - metabolism mammals Methylation precipitin tests Protein Binding - genetics regulatory proteins Regulatory Sequences, Nucleic Acid - genetics RNA transcription (genetics) Transcription Initiation Site Zebrafish Zebrafish - embryology Zebrafish - genetics Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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