Simple model of forebrain ischemia in mouse

► Article describes a simple model of forebrain ischemia in mouse. ► The described model of transient global ischemia gives rise to cell death mainly in the CA1 sector and partially in the dentate gyrus sub-region of the hippocampus. ► The cell death is delayed and matures after 3 days of recovery....

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Veröffentlicht in:	Journal of neuroscience methods 2012-03, Vol.204 (2), p.254-261
Hauptverfasser:	Onken, Mitch, Berger, Stephanie, Kristian, Tibor
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Inhalation - adverse effects Animals Blood Pressure - drug effects Blood Pressure - physiology Brain Ischemia - pathology Brain Ischemia - physiopathology Cell death Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Disease Models, Animal Exploratory Behavior Fluoresceins Global cerebral ischemia Hypertension - chemically induced Hypotension Isoflurane Isoflurane - adverse effects Laser-Doppler Flowmetry Male Mice Mice, Inbred C57BL Motor Activity - physiology Mouse Neurons - pathology Organic Chemicals Prosencephalon - pathology Prosencephalon - physiopathology Regional Blood Flow - drug effects Regional Blood Flow - physiology Stereotaxic Techniques
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