Poly-IC Preconditioning Protects against Cerebral and Renal Ischemia-Reperfusion Injury

Preconditioning induces ischemic tolerance, which confers robust protection against ischemic damage. We show marked protection with polyinosinic polycytidylic acid (poly-IC) preconditioning in three models of murine ischemia-reperfusion injury. Poly-IC preconditioning induced protection against isch...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2012-02, Vol.32 (2), p.242-247
Hauptverfasser:	Packard, Amy E B, Hedges, Jason C, Bahjat, Frances R, Stevens, Susan L, Conlin, Michael J, Salazar, Andres M, Stenzel-Poore, Mary P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - drug effects Brain - physiopathology Brain Ischemia - physiopathology Brain Ischemia - prevention & control Brief Communication Cells, Cultured Cytokines - blood Interferon Inducers - therapeutic use Ischemic Preconditioning - methods Kidney - drug effects Kidney - physiopathology Kidney Diseases - physiopathology Kidney Diseases - prevention & control Male Medical sciences Mice Mice, Inbred C57BL Neurology Neuropharmacology Neuroprotective agent Neuroprotective Agents - therapeutic use Pharmacology. Drug treatments Poly I-C - therapeutic use Reperfusion Injury - physiopathology Reperfusion Injury - prevention & control Vascular diseases and vascular malformations of the nervous system
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