Cerebral Microvascular Inflammation in DOCA Salt-Induced Hypertension: Role of Angiotensin II and Mitochondrial Superoxide

Angiotensin II-mediated hypertension (HTN) is accompanied by a pro-inflammatory and pro-thrombotic state in the cerebral microvasculature. Whether comparable phenotypic changes are elicited in other models of HTN remains unclear. Using wild-type mice with deoxycorticosterone acetate (DOCA) salt-indu...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2012-02, Vol.32 (2), p.368-375
Hauptverfasser:	Rodrigues, Stephen F, Granger, Daniel Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - immunology Animals Antihypertensive agents Biological and medical sciences Blood Platelets - cytology Blood Platelets - drug effects Blood Platelets - immunology Blood Pressure - drug effects Brain - blood supply Brain - immunology Cardiovascular system Cell Adhesion - drug effects Cytokines - blood Desoxycorticosterone - adverse effects Hypertension - chemically induced Hypertension - immunology Leukocytes - cytology Leukocytes - drug effects Leukocytes - immunology Male Medical sciences Mice Mice, Inbred C57BL Microvessels - drug effects Mineralocorticoids - adverse effects Mitochondria - immunology Neurology Original Pharmacology. Drug treatments Reactive Oxygen Species - immunology Stroke - immunology Superoxides - immunology Vascular diseases and vascular malformations of the nervous system
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