Chemoenzymatic Synthesis of Uridine Diphosphate-GlcNAc and Uridine Diphosphate-GalNAc Analogs for the Preparation of Unnatural Glycosaminoglycans

Eight N-acetylglucosamine-1-phosphate and N-acetylgalactosamine-1-phosphate analogs have been synthesized chemically and were tested for their recognition by the GlmU uridyltransferase enzyme. Among these, only substrates that have an amide linkage to the C-2 nitrogen were transferred by GlmU to aff...

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Veröffentlicht in:	Journal of organic chemistry 2012-02, Vol.77 (3), p.1449-1456
Hauptverfasser:	Masuko, Sayaka, Bera, Smritilekha, Green, Dixy E, Weïwer, Michel, Liu, Jian, DeAngelis, Paul L, Linhardt, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides Carbohydrates. Nucleosides and nucleotides Chemistry Chemistry Techniques, Synthetic - methods Escherichia coli Proteins - metabolism Exact sciences and technology Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Multienzyme Complexes - metabolism Nucleosides, nucleotides and oligonucleotides Organic chemistry Organometalloidal and organometallic compounds P derivatives Polymerization Preparations and properties Uridine Diphosphate N-Acetylglucosamine - analogs & derivatives Uridine Diphosphate N-Acetylglucosamine - chemical synthesis
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