Role of Prostaglandin E2-Dependent Angiogenic Switch in Cyclooxygenase 2-Induced Breast Cancer Progression

Overexpression of human cyclooxygenase 2 (COX-2) in the mammary glands of transgenic mice induces tissue-specific tumorigenic transformation. However, the molecular mechanisms involved are not yet defined. Here we show that COX-2 expressed in the epithelial cell compartment regulates angiogenesis in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-01, Vol.101 (2), p.591-596
Hauptverfasser:	Chang, Sung-Hee, Liu, Catherine H., Conway, Rebecca, Han, David K., Nithipatikom, Kasem, Trifan, Ovidiu C., Lane, Timothy F., Hla, Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Biological Sciences Breast cancer Chromatography, Liquid Cyclooxygenase 2 Dinoprostone - physiology Disease Progression Epithelial cells Fatty acids Isoenzymes - physiology Mammary glands Mammary Neoplasms, Experimental - blood supply Mammary Neoplasms, Experimental - pathology Medical research Mice Mice, Nude Microvessels Neovascularization, Pathologic - physiopathology Prostaglandin-Endoperoxide Synthases - physiology Prostaglandins Receptors Reverse transcriptase polymerase chain reaction Spectrometry, Mass, Electrospray Ionization Transgenic animals Tumors
Online-Zugang:	Volltext
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