Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

Connexin 43 (Cx43) mediates osteocyte communication with other cells and with the extracellular milieu and regulates osteoblastic cell signaling and gene expression. We now report that mice lacking Cx43 in osteoblasts/osteocytes or only in osteocytes (Cx43ΔOt mice) exhibit increased osteocyte apopto...

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Veröffentlicht in:	Journal of bone and mineral research 2012-02, Vol.27 (2), p.374-389
Hauptverfasser:	Bivi, Nicoletta, Condon, Keith W, Allen, Matthew R, Farlow, Nathan, Passeri, Giovanni, Brun, Lucas R, Rhee, Yumie, Bellido, Teresita, Plotkin, Lilian I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals APOPTOSIS Biological and medical sciences BONE RESORPTION Bone Resorption - diagnostic imaging Bone Resorption - metabolism Bone Resorption - pathology Cell Survival CONNEXIN 43 Connexin 43 - deficiency Connexin 43 - metabolism Femur - diagnostic imaging Femur - metabolism Femur - pathology Femur - ultrastructure Fundamental and applied biological sciences. Psychology Gene Deletion Glycoproteins - metabolism Intercellular Signaling Peptides and Proteins Mice Models, Biological OSTEOBLAST Osteoblasts - metabolism Osteoblasts - pathology OSTEOCYTE Osteocytes - metabolism Osteocytes - pathology Osteocytes - ultrastructure Osteogenesis OSTEOPROTEGERIN PERIOSTEAL BONE FORMATION Periosteum - diagnostic imaging Periosteum - metabolism Periosteum - pathology RANK Ligand - metabolism Skeleton and joints SOST/SCLEROSTIN Vertebrates: osteoarticular system, musculoskeletal system X-Ray Microtomography
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