A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21q

Approximately half of all human genes have CpG islands (CGIs)around their promoter regions. Although CGIs usually escape methylation, those on Chromosome X in females and those in the vicinity of imprinted genes are exceptions: They have both methylated and unmethylated alleles to display a "co...

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Veröffentlicht in:	Genome research 2004-02, Vol.14 (2), p.247-266
Hauptverfasser:	Yamada, Yoichi, Watanabe, Hidemi, Miura, Fumihito, Soejima, Hidenobu, Uchiyama, Michiko, Iwasaka, Tsuyoshi, Mukai, Tsunehiro, Sakaki, Yoshiyuki, Ito, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Chromosome Mapping - methods Chromosomes, Human, Pair 21 - genetics Computational Biology - methods CpG Islands - genetics DNA - blood DNA - metabolism DNA Methylation Female Humans Letters Leukocytes - chemistry Male Mosaicism - genetics Placenta - chemistry Polymerase Chain Reaction - methods Polymorphism, Single Nucleotide - genetics Research Design Sequence Analysis, DNA - methods
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