Asymmetrical distribution of CpG in an ‘average’ mammalian gene

The frequency and distribution of the rare dinucleotide CpG was examined in 15 mammalian genes. CpG is highly methylated at cytosine in mammalian DNA (1,2) and 5-methylcytosine (5mC) is thought to undergo a transition mutation via examination to produce thyraine (3). This would result in the accumul...

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Veröffentlicht in:	Nucleic acids research 1982-12, Vol.10 (23), p.7865-7877
Hauptverfasser:	McClelland, Michael, Ivarie, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cytidine Monophosphate - analogs & derivatives Cytidine Monophosphate - analysis Cytosine Nucleotides - analysis Dinucleoside Phosphates DNA Genes Guanosine - analogs & derivatives Guanosine - analysis Humans Methylation Protein Biosynthesis
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