Why do anti-inflammatory therapies fail to improve insulin sensitivity

Chronic inflammation occurs in obese conditions in both humans and animals. It also contributes to the pathogenesis of type 2 diabetes （T2D） through insulin resistance, a status in which the body loses its ability to respond to insulin. Inflammation impairs insulin signaling through the functional i...

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Veröffentlicht in:	Acta pharmacologica Sinica 2012-02, Vol.33 (2), p.182-188
Hauptverfasser:	Gao, Zhan-guo, Ye, Jian-ping
Format:	Artikel
Sprache:	eng
Schlagworte:	2型糖尿病 Animals Anti-Inflammatory Agents - immunology Anti-Inflammatory Agents - therapeutic use Biomedical and Life Sciences Biomedicine Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - immunology Humans Immunology Inflammation - complications Inflammation - drug therapy Inflammation - immunology Insulin Resistance - immunology Internal Medicine Medical Microbiology Obesity - complications Obesity - drug therapy Obesity - immunology Pharmacology/Toxicology Review Vaccine 慢性炎症敏感性治疗消炎药生物学意义胰岛素增敏剂胰岛素抵抗
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