Obesity is associated with impaired immune response to influenza vaccination in humans

Background: Obesity is an independent risk factor for morbidity and mortality from pandemic influenza H1N1. Influenza is a significant public health threat, killing an estimated 250 000–500 000 people worldwide each year. More than one in ten of the world's adult population is obese and more th...

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Veröffentlicht in:	International Journal of Obesity 2012-08, Vol.36 (8), p.1072-1077
Hauptverfasser:	Sheridan, P A, Paich, H A, Handy, J, Karlsson, E A, Hudgens, M G, Sammon, A B, Holland, L A, Weir, S, Noah, T L, Beck, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1933 631/250/251/1567 631/326/596/1578 692/699/2743/393 Adult Antibodies Antibodies, Viral - immunology Antibody Formation - immunology Antibody response Antigens Biological and medical sciences Body mass index Body weight CD8 antigen Cell activation Cell culture Cells, Cultured Complications and side effects Enrollments Enzyme-Linked Immunosorbent Assay Enzymes Epidemiology Female gamma -Interferon granzyme B Granzymes - metabolism Health aspects Health care Health Promotion and Disease Prevention Health risks Hemagglutination Inhibition Tests Human viral diseases Humans Immune response Immune response (humoral) Immunoglobulin G Infectious diseases Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza vaccines Influenza Vaccines - adverse effects Influenza Vaccines - immunology Influenza virus Interferon-gamma - metabolism Internal Medicine Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocytes T Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Morbidity Mortality Nutrition Obesity Obesity - complications Obesity - immunology Observational studies Original original-article Overweight Pandemics Peripheral blood mononuclear cells Physiological aspects Prevention and actions Proteins Public Health Public health. Hygiene Public health. Hygiene-occupational medicine Risk factors Vaccination Vaccines Viral diseases Viral diseases of the respiratory system and ent viral diseases
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