Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor
The identity of the interstitial light atom in the center of the FeMo cofactor of nitrogenase has been enigmatic since its discovery. Atomic-resolution x-ray diffraction data and an electron spin echo envelope modulation (ESEEM) analysis now provide direct evidence that the ligand is a carbon specie...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2011-11, Vol.334 (6058), p.940-940 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 940 |
|---|---|
| container_issue | 6058 |
| container_start_page | 940 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 334 |
| creator | Spatzal, Thomas Aksoyoglu, Müge Zhang, Limei Andrade, Susana L. A. Schleicher, Erik Weber, Stefan Rees, Douglas C. Einsle, Oliver |
| description | The identity of the interstitial light atom in the center of the FeMo cofactor of nitrogenase has been enigmatic since its discovery. Atomic-resolution x-ray diffraction data and an electron spin echo envelope modulation (ESEEM) analysis now provide direct evidence that the ligand is a carbon species. |
| doi_str_mv | 10.1126/science.1214025 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3268367</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>41351736</jstor_id><sourcerecordid>41351736</sourcerecordid><originalsourceid>FETCH-LOGICAL-c570t-461519bc358bb397194c3e677e8ce464a2f519931a74d5932081855886f79c853</originalsourceid><addsrcrecordid>eNp9kT1vFDEYhC1ERC4HNRVohRRBs4lff7sACZ0SEimBBmrL6_MGn_bsYO9F4t_j1S3HR5HKxTzvaDyD0EvAZwBEnBcXfHT-DAgwTPgTtACseasJpk_RAmMqWoUlP0YnpWwwrpqmz9AxIVgL0HiB3l88hPVk0fQpN9dx9LmMYQx2aFY2dyk2ITafw5jTnY-2-ObS36ZmlXrrxpSfo6PeDsW_mN8l-nZ58XV11d58-XS9-njTOi7x2DIBHHTnKFddR7UEzRz1QkqvnGeCWdJXXVOwkq1rQoIVKM6VEr3UTnG6RB_2vve7buvXzscx28Hc57C1-adJNph_lRi-m7v0YCgRigpZDd7OBjn92Pkymm0ozg-DjT7titGYCwmUQiXfPUqS2iJleoKX6M1_6CbtcqxFVD_GCQc8RT_fQy6nUrLvD6kBm2lDM29o5g3rxeu_P3vgf49WgdMZsMXZoc82ulD-cKy2B3QyerXnNqVuddBZ1UBSQX8B-zus3Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>904525105</pqid></control><display><type>article</type><title>Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor</title><source>American Association for the Advancement of Science</source><source>MEDLINE</source><source>JSTOR</source><creator>Spatzal, Thomas ; Aksoyoglu, Müge ; Zhang, Limei ; Andrade, Susana L. A. ; Schleicher, Erik ; Weber, Stefan ; Rees, Douglas C. ; Einsle, Oliver</creator><creatorcontrib>Spatzal, Thomas ; Aksoyoglu, Müge ; Zhang, Limei ; Andrade, Susana L. A. ; Schleicher, Erik ; Weber, Stefan ; Rees, Douglas C. ; Einsle, Oliver</creatorcontrib><description>The identity of the interstitial light atom in the center of the FeMo cofactor of nitrogenase has been enigmatic since its discovery. Atomic-resolution x-ray diffraction data and an electron spin echo envelope modulation (ESEEM) analysis now provide direct evidence that the ligand is a carbon species.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1214025</identifier><identifier>PMID: 22096190</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Atoms ; Azotobacter vinelandii - chemistry ; Biological and medical sciences ; BREVIA ; Carbon ; Carbon - chemistry ; Catalysis ; Crystalline structure ; Crystallography, X-Ray ; Electron Spin Resonance Spectroscopy ; Evidence ; Fundamental and applied biological sciences. Psychology ; Isotopic labeling ; ligands ; Models, Molecular ; Molecular biophysics ; Molecular Structure ; Molybdoferredoxin - chemistry ; Nitrogen ; Nitrogen - chemistry ; nitrogenase ; Structure in molecular biology ; X-ray diffraction</subject><ispartof>Science (American Association for the Advancement of Science), 2011-11, Vol.334 (6058), p.940-940</ispartof><rights>Copyright © 2011 American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-461519bc358bb397194c3e677e8ce464a2f519931a74d5932081855886f79c853</citedby><cites>FETCH-LOGICAL-c570t-461519bc358bb397194c3e677e8ce464a2f519931a74d5932081855886f79c853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41351736$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41351736$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24818135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22096190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spatzal, Thomas</creatorcontrib><creatorcontrib>Aksoyoglu, Müge</creatorcontrib><creatorcontrib>Zhang, Limei</creatorcontrib><creatorcontrib>Andrade, Susana L. A.</creatorcontrib><creatorcontrib>Schleicher, Erik</creatorcontrib><creatorcontrib>Weber, Stefan</creatorcontrib><creatorcontrib>Rees, Douglas C.</creatorcontrib><creatorcontrib>Einsle, Oliver</creatorcontrib><title>Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The identity of the interstitial light atom in the center of the FeMo cofactor of nitrogenase has been enigmatic since its discovery. Atomic-resolution x-ray diffraction data and an electron spin echo envelope modulation (ESEEM) analysis now provide direct evidence that the ligand is a carbon species.</description><subject>Atoms</subject><subject>Azotobacter vinelandii - chemistry</subject><subject>Biological and medical sciences</subject><subject>BREVIA</subject><subject>Carbon</subject><subject>Carbon - chemistry</subject><subject>Catalysis</subject><subject>Crystalline structure</subject><subject>Crystallography, X-Ray</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Evidence</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Isotopic labeling</subject><subject>ligands</subject><subject>Models, Molecular</subject><subject>Molecular biophysics</subject><subject>Molecular Structure</subject><subject>Molybdoferredoxin - chemistry</subject><subject>Nitrogen</subject><subject>Nitrogen - chemistry</subject><subject>nitrogenase</subject><subject>Structure in molecular biology</subject><subject>X-ray diffraction</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kT1vFDEYhC1ERC4HNRVohRRBs4lff7sACZ0SEimBBmrL6_MGn_bsYO9F4t_j1S3HR5HKxTzvaDyD0EvAZwBEnBcXfHT-DAgwTPgTtACseasJpk_RAmMqWoUlP0YnpWwwrpqmz9AxIVgL0HiB3l88hPVk0fQpN9dx9LmMYQx2aFY2dyk2ITafw5jTnY-2-ObS36ZmlXrrxpSfo6PeDsW_mN8l-nZ58XV11d58-XS9-njTOi7x2DIBHHTnKFddR7UEzRz1QkqvnGeCWdJXXVOwkq1rQoIVKM6VEr3UTnG6RB_2vve7buvXzscx28Hc57C1-adJNph_lRi-m7v0YCgRigpZDd7OBjn92Pkymm0ozg-DjT7titGYCwmUQiXfPUqS2iJleoKX6M1_6CbtcqxFVD_GCQc8RT_fQy6nUrLvD6kBm2lDM29o5g3rxeu_P3vgf49WgdMZsMXZoc82ulD-cKy2B3QyerXnNqVuddBZ1UBSQX8B-zus3Q</recordid><startdate>20111118</startdate><enddate>20111118</enddate><creator>Spatzal, Thomas</creator><creator>Aksoyoglu, Müge</creator><creator>Zhang, Limei</creator><creator>Andrade, Susana L. A.</creator><creator>Schleicher, Erik</creator><creator>Weber, Stefan</creator><creator>Rees, Douglas C.</creator><creator>Einsle, Oliver</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111118</creationdate><title>Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor</title><author>Spatzal, Thomas ; Aksoyoglu, Müge ; Zhang, Limei ; Andrade, Susana L. A. ; Schleicher, Erik ; Weber, Stefan ; Rees, Douglas C. ; Einsle, Oliver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-461519bc358bb397194c3e677e8ce464a2f519931a74d5932081855886f79c853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Atoms</topic><topic>Azotobacter vinelandii - chemistry</topic><topic>Biological and medical sciences</topic><topic>BREVIA</topic><topic>Carbon</topic><topic>Carbon - chemistry</topic><topic>Catalysis</topic><topic>Crystalline structure</topic><topic>Crystallography, X-Ray</topic><topic>Electron Spin Resonance Spectroscopy</topic><topic>Evidence</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Isotopic labeling</topic><topic>ligands</topic><topic>Models, Molecular</topic><topic>Molecular biophysics</topic><topic>Molecular Structure</topic><topic>Molybdoferredoxin - chemistry</topic><topic>Nitrogen</topic><topic>Nitrogen - chemistry</topic><topic>nitrogenase</topic><topic>Structure in molecular biology</topic><topic>X-ray diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spatzal, Thomas</creatorcontrib><creatorcontrib>Aksoyoglu, Müge</creatorcontrib><creatorcontrib>Zhang, Limei</creatorcontrib><creatorcontrib>Andrade, Susana L. A.</creatorcontrib><creatorcontrib>Schleicher, Erik</creatorcontrib><creatorcontrib>Weber, Stefan</creatorcontrib><creatorcontrib>Rees, Douglas C.</creatorcontrib><creatorcontrib>Einsle, Oliver</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spatzal, Thomas</au><au>Aksoyoglu, Müge</au><au>Zhang, Limei</au><au>Andrade, Susana L. A.</au><au>Schleicher, Erik</au><au>Weber, Stefan</au><au>Rees, Douglas C.</au><au>Einsle, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2011-11-18</date><risdate>2011</risdate><volume>334</volume><issue>6058</issue><spage>940</spage><epage>940</epage><pages>940-940</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The identity of the interstitial light atom in the center of the FeMo cofactor of nitrogenase has been enigmatic since its discovery. Atomic-resolution x-ray diffraction data and an electron spin echo envelope modulation (ESEEM) analysis now provide direct evidence that the ligand is a carbon species.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>22096190</pmid><doi>10.1126/science.1214025</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2011-11, Vol.334 (6058), p.940-940 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3268367 |
| source | American Association for the Advancement of Science; MEDLINE; JSTOR |
| subjects | Atoms Azotobacter vinelandii - chemistry Biological and medical sciences BREVIA Carbon Carbon - chemistry Catalysis Crystalline structure Crystallography, X-Ray Electron Spin Resonance Spectroscopy Evidence Fundamental and applied biological sciences. Psychology Isotopic labeling ligands Models, Molecular Molecular biophysics Molecular Structure Molybdoferredoxin - chemistry Nitrogen Nitrogen - chemistry nitrogenase Structure in molecular biology X-ray diffraction |
| title | Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T19%3A46%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evidence%20for%20Interstitial%20Carbon%20in%20Nitrogenase%20FeMo%20Cofactor&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Spatzal,%20Thomas&rft.date=2011-11-18&rft.volume=334&rft.issue=6058&rft.spage=940&rft.epage=940&rft.pages=940-940&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1214025&rft_dat=%3Cjstor_pubme%3E41351736%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=904525105&rft_id=info:pmid/22096190&rft_jstor_id=41351736&rfr_iscdi=true |