Prostaglandin E2 induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves

BACKGROUND AND PURPOSE The acute effects of PGE2 on bladder smooth muscle and nerves were examined to determine the origin of PGE2‐induced spontaneous rhythmic contractions. EXPERIMENTAL APPROACH Contraction studies, confocal Ca2+ imaging and electrophysiological recordings in strips of mouse urinar...

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Veröffentlicht in:	British journal of pharmacology 2012-01, Vol.165 (2), p.401-413
Hauptverfasser:	Kobayter, S, Young, JS, Brain, KL
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzenesulfonates - pharmacology Biological and medical sciences calcium Calcium - physiology Dinoprostone - physiology Female In Vitro Techniques Medical sciences Mice Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - innervation Muscle, Smooth - physiology Neurons, Efferent - drug effects Neurons, Efferent - physiology parasympathetic nervous system Pharmacology. Drug treatments Prostaglandin Antagonists - pharmacology prostaglandin E Purinergic P2X Receptor Antagonists - pharmacology Research Papers smooth muscle Sodium Channel Blockers - pharmacology Tetrodotoxin - pharmacology urinary bladder Urinary Bladder - drug effects Urinary Bladder - innervation Urinary Bladder - physiology Xanthones - pharmacology
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