Brain reinforcement system function is ghrelin dependent: studies in the rat using pharmacological fMRI and intracranial self-stimulation

ABSTRACT Ghrelin (GHR) is an orexigenic gut peptide that interacts with brain ghrelin receptors (GHR‐Rs) to promote food intake. Recent research suggests that GHR acts as a modulator of motivated behavior, suggesting a direct influence of GHR on brain reinforcement circuits. In the present studies,...

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