Neck-motor interactions trigger rotation of the kinesin stalk

Rotation of the coiled-coil stalk of the kinesin-14 motors is thought to drive displacements or steps by the motor along microtubules, but the structural changes that trigger stalk rotation and the nucleotide state in which it occurs are not certain. Here we report a kinesin-14 neck mutant that rele...

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Veröffentlicht in:	Sci. Rep 2012-01, Vol.2 (1), p.236-236, Article 236
Hauptverfasser:	Liu, Hong-Lei, Pemble IV, Charles W., Endow, Sharyn A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/607 631/45/607/731 Adenosine diphosphate Affinity Crystal structure Crystallography, X-Ray Humanities and Social Sciences Kinesin Kinesins - chemistry Kinesins - metabolism Kinesins - physiology Kinetics Microtubules Microtubules - metabolism Models, Molecular Motor task performance multidisciplinary Neck Science Stroke
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