Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice

A complex biologic network regulates kidney perfusion under physiologic conditions. This system is profoundly perturbed following renal ischemia, a leading cause of acute kidney injury (AKI) - a life-threatening condition that frequently complicates the care of hospitalized patients. Therapeutic app...

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Veröffentlicht in:	The Journal of clinical investigation 2012-02, Vol.122 (2), p.693-710
Hauptverfasser:	Grenz, Almut, Bauerle, Jessica D, Dalton, Julee H, Ridyard, Douglas, Badulak, Alexander, Tak, Eunyoung, McNamee, Eóin N, Clambey, Eric, Moldovan, Radu, Reyes, German, Klawitter, Jost, Ambler, Kelly, Magee, Kristann, Christians, Uwe, Brodsky, Kelley S, Ravid, Katya, Choi, Doo-Sup, Wen, Jiaming, Lukashev, Dmitriy, Blackburn, Michael R, Osswald, Hartmut, Coe, Imogen R, Nürnberg, Bernd, Haase, Volker H, Xia, Yang, Sitkovsky, Michail, Eltzschig, Holger K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - drug therapy Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Adenosine Adenosine - metabolism Animals Apoptosis Biomedical research Blood flow Cell Line Chimerism Diagnosis Dipyridamole - therapeutic use Equilibrative Nucleoside Transporter 1 - antagonists & inhibitors Equilibrative Nucleoside Transporter 1 - genetics Equilibrative Nucleoside Transporter 1 - metabolism Humans Hypotheses Hypoxia Ischemia Ischemia - metabolism Kidney - metabolism Kidney - pathology Kidney diseases Kidneys Measurement Mice Mice, Inbred C57BL Mice, Knockout Mortality No-Reflow Phenomenon Nucleoside Transport Proteins - antagonists & inhibitors Nucleoside Transport Proteins - metabolism Nucleosides Phosphodiesterase Inhibitors - therapeutic use Physiological aspects Polyethylene glycol Receptors, Purinergic P1 - genetics Receptors, Purinergic P1 - metabolism Regional Blood Flow - physiology Risk factors Sepsis
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