Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance
To characterize the defects in β-cell function in subjects with impaired fasting glucose (IFG) and compare the results to impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) subjects, β-cell glucose sensitivity and rate sensitivity during the oral glucose tolerance test were measured...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2012-02, Vol.61 (2), p.447-453 |
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| creator | KANAT, Mustafa MARI, Andrea NORTON, Luke WINNIER, Diedre DEFRONZO, Ralph A JENKINSON, Chris ABDUL-GHANI, Muhammad A |
| description | To characterize the defects in β-cell function in subjects with impaired fasting glucose (IFG) and compare the results to impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) subjects, β-cell glucose sensitivity and rate sensitivity during the oral glucose tolerance test were measured with the model by Mari in 172 Mexican Americans. A subgroup (n=70) received a 2-h hyperglycemic clamp (+125 mg/dL), and first- and second-phase insulin secretion were quantitated. Compared with NGT, subjects with IFG and IGT manifested a decrease in β-cell glucose sensitivity; IFG subjects, but not IGT subjects, had decreased β-cell rate sensitivity. In IFG subjects, the defect in β-cell glucose sensitivity was time dependent, began to improve after 60 min, and was comparable to NGT after 90 min. The incremental area under the plasma C-peptide concentration curve during the first 12 min of the hyperglycemic clamp (ΔC-pep[AUC]0-12) was inversely related with the increase in FPG concentration (r=-36, r=0.001), whereas ΔC-pep[AUC]15-120 positively correlated with FPG concentration (r=0.29, r |
| doi_str_mv | 10.2337/db11-0995 |
| format | Article |
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A subgroup (n=70) received a 2-h hyperglycemic clamp (+125 mg/dL), and first- and second-phase insulin secretion were quantitated. Compared with NGT, subjects with IFG and IGT manifested a decrease in β-cell glucose sensitivity; IFG subjects, but not IGT subjects, had decreased β-cell rate sensitivity. In IFG subjects, the defect in β-cell glucose sensitivity was time dependent, began to improve after 60 min, and was comparable to NGT after 90 min. The incremental area under the plasma C-peptide concentration curve during the first 12 min of the hyperglycemic clamp (ΔC-pep[AUC]0-12) was inversely related with the increase in FPG concentration (r=-36, r=0.001), whereas ΔC-pep[AUC]15-120 positively correlated with FPG concentration (r=0.29, r<0.05). When adjusted for the prevailing level of insulin resistance, first-phase insulin secretion was markedly decreased in both IFG and IGT, whereas second-phase insulin secretion was decreased only in IGT. These results demonstrate distinct defects in β-cell function in IFG and IGT.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db11-0995</identifier><identifier>PMID: 22275086</identifier><identifier>CODEN: DIAEAZ</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adult ; Analysis ; Area Under Curve ; Biological and medical sciences ; Blood Glucose - analysis ; Blood sugar monitoring ; Comparative analysis ; Demographic aspects ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fasting - blood ; Female ; Glucose Intolerance - blood ; Glucose Intolerance - physiopathology ; Glucose Tolerance Test ; Humans ; Insulin Resistance ; Insulin-Secreting Cells - physiology ; Male ; Medical sciences ; Middle Aged ; Pancreatic beta cells ; Pathophysiology</subject><ispartof>Diabetes (New York, N.Y.), 2012-02, Vol.61 (2), p.447-453</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 American Diabetes Association</rights><rights>2012 by the American Diabetes Association. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-49b318d0be7f7e45abea2cdaead9f643509054fb7c35dae7ef66c1a0f0eea1433</citedby><cites>FETCH-LOGICAL-c543t-49b318d0be7f7e45abea2cdaead9f643509054fb7c35dae7ef66c1a0f0eea1433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266412/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266412/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25594820$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22275086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KANAT, Mustafa</creatorcontrib><creatorcontrib>MARI, Andrea</creatorcontrib><creatorcontrib>NORTON, Luke</creatorcontrib><creatorcontrib>WINNIER, Diedre</creatorcontrib><creatorcontrib>DEFRONZO, Ralph A</creatorcontrib><creatorcontrib>JENKINSON, Chris</creatorcontrib><creatorcontrib>ABDUL-GHANI, Muhammad A</creatorcontrib><title>Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance</title><title>Diabetes (New York, N.Y.)</title><addtitle>Diabetes</addtitle><description>To characterize the defects in β-cell function in subjects with impaired fasting glucose (IFG) and compare the results to impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) subjects, β-cell glucose sensitivity and rate sensitivity during the oral glucose tolerance test were measured with the model by Mari in 172 Mexican Americans. A subgroup (n=70) received a 2-h hyperglycemic clamp (+125 mg/dL), and first- and second-phase insulin secretion were quantitated. Compared with NGT, subjects with IFG and IGT manifested a decrease in β-cell glucose sensitivity; IFG subjects, but not IGT subjects, had decreased β-cell rate sensitivity. In IFG subjects, the defect in β-cell glucose sensitivity was time dependent, began to improve after 60 min, and was comparable to NGT after 90 min. The incremental area under the plasma C-peptide concentration curve during the first 12 min of the hyperglycemic clamp (ΔC-pep[AUC]0-12) was inversely related with the increase in FPG concentration (r=-36, r=0.001), whereas ΔC-pep[AUC]15-120 positively correlated with FPG concentration (r=0.29, r<0.05). When adjusted for the prevailing level of insulin resistance, first-phase insulin secretion was markedly decreased in both IFG and IGT, whereas second-phase insulin secretion was decreased only in IGT. These results demonstrate distinct defects in β-cell function in IFG and IGT.</description><subject>Adult</subject><subject>Analysis</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Blood sugar monitoring</subject><subject>Comparative analysis</subject><subject>Demographic aspects</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Glucose Intolerance - blood</subject><subject>Glucose Intolerance - physiopathology</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Insulin-Secreting Cells - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pancreatic beta cells</subject><subject>Pathophysiology</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptks2KFDEQx4Mo7rh68AWkQTx46DUfnU7nIiyz7rgw4MEVvIXqdKWNpNNDp2fR1_JBfCbT7JcDQx0C__pVUZX6E_Ka0TMuhPrQtYyVVGv5hKyYFroUXH1_SlaUMl4ypdUJeZHST0ppneM5OeGcK0mbekW-Xvg0-2jn4u-fco0hFBfo0M6p8LG4GnbgJ-yKS1igvtiEvR0TFhC7x-S9eD0GnCBafEmeOQgJX929p-Tb5afr9edy-2VztT7fllZWYi4r3QrWdLRF5RRWEloEbjtA6LSrKyGpprJyrbJCZlWhq2vLgDqKCKwS4pR8vO2727cDdhbjPEEwu8kPMP02I3hzmIn-h-nHGyN4XVeM5wZvbxv0END46MaM2cEna865avIASjSZKo9QPca8bRgjOp_lA_7sCJ-jw8HbowXvDwoyM-OvuYd9SqbZbI-ydhpTmtA9rMuoWcxgFjOYxQyZffP__zyQ99fPwLs7AJKF4Jbr-fTISamrhlPxD9g2u_4</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>KANAT, Mustafa</creator><creator>MARI, Andrea</creator><creator>NORTON, Luke</creator><creator>WINNIER, Diedre</creator><creator>DEFRONZO, Ralph A</creator><creator>JENKINSON, Chris</creator><creator>ABDUL-GHANI, Muhammad A</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>5PM</scope></search><sort><creationdate>20120201</creationdate><title>Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance</title><author>KANAT, Mustafa ; MARI, Andrea ; NORTON, Luke ; WINNIER, Diedre ; DEFRONZO, Ralph A ; JENKINSON, Chris ; ABDUL-GHANI, Muhammad A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-49b318d0be7f7e45abea2cdaead9f643509054fb7c35dae7ef66c1a0f0eea1433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Blood sugar monitoring</topic><topic>Comparative analysis</topic><topic>Demographic aspects</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Glucose Intolerance - blood</topic><topic>Glucose Intolerance - physiopathology</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Insulin-Secreting Cells - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pancreatic beta cells</topic><topic>Pathophysiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KANAT, Mustafa</creatorcontrib><creatorcontrib>MARI, Andrea</creatorcontrib><creatorcontrib>NORTON, Luke</creatorcontrib><creatorcontrib>WINNIER, Diedre</creatorcontrib><creatorcontrib>DEFRONZO, Ralph A</creatorcontrib><creatorcontrib>JENKINSON, Chris</creatorcontrib><creatorcontrib>ABDUL-GHANI, Muhammad A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KANAT, Mustafa</au><au>MARI, Andrea</au><au>NORTON, Luke</au><au>WINNIER, Diedre</au><au>DEFRONZO, Ralph A</au><au>JENKINSON, Chris</au><au>ABDUL-GHANI, Muhammad A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><addtitle>Diabetes</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>61</volume><issue>2</issue><spage>447</spage><epage>453</epage><pages>447-453</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><coden>DIAEAZ</coden><abstract>To characterize the defects in β-cell function in subjects with impaired fasting glucose (IFG) and compare the results to impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) subjects, β-cell glucose sensitivity and rate sensitivity during the oral glucose tolerance test were measured with the model by Mari in 172 Mexican Americans. A subgroup (n=70) received a 2-h hyperglycemic clamp (+125 mg/dL), and first- and second-phase insulin secretion were quantitated. Compared with NGT, subjects with IFG and IGT manifested a decrease in β-cell glucose sensitivity; IFG subjects, but not IGT subjects, had decreased β-cell rate sensitivity. In IFG subjects, the defect in β-cell glucose sensitivity was time dependent, began to improve after 60 min, and was comparable to NGT after 90 min. The incremental area under the plasma C-peptide concentration curve during the first 12 min of the hyperglycemic clamp (ΔC-pep[AUC]0-12) was inversely related with the increase in FPG concentration (r=-36, r=0.001), whereas ΔC-pep[AUC]15-120 positively correlated with FPG concentration (r=0.29, r<0.05). When adjusted for the prevailing level of insulin resistance, first-phase insulin secretion was markedly decreased in both IFG and IGT, whereas second-phase insulin secretion was decreased only in IGT. These results demonstrate distinct defects in β-cell function in IFG and IGT.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>22275086</pmid><doi>10.2337/db11-0995</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes (New York, N.Y.), 2012-02, Vol.61 (2), p.447-453 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload; PubMed Central |
| subjects | Adult Analysis Area Under Curve Biological and medical sciences Blood Glucose - analysis Blood sugar monitoring Comparative analysis Demographic aspects Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fasting - blood Female Glucose Intolerance - blood Glucose Intolerance - physiopathology Glucose Tolerance Test Humans Insulin Resistance Insulin-Secreting Cells - physiology Male Medical sciences Middle Aged Pancreatic beta cells Pathophysiology |
| title | Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance |
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