Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion

As patients decline from health to type 2 diabetes, glucose-stimulated insulin secretion (GSIS) typically becomes impaired. Although GSIS is driven predominantly by direct sensing of a rise in blood glucose by pancreatic β-cells, there is growing evidence that hypothalamic neurons control other aspe...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2012-02, Vol.61 (2), p.321-328
Hauptverfasser:	OSUNDIJI, Mayowa A, LAM, Daniel D, SHAW, Jill, YUEH, Chen-Yu, PAULIINA MARKKULA, S, HURST, Paul, COLLIVA, Carolina, RODA, Aldo, HEISLER, Lora K, EVANS, Mark L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beta cells Biological and medical sciences Blood Brain Chemoreception Data processing Diabetes Diabetes mellitus Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucokinase Glucokinase - physiology Glucosamine Glucose Glucose - metabolism Glucose - pharmacology Glucose tolerance Glucose Tolerance Test Hypothalamus Hypothalamus - drug effects Hypothalamus - physiology Injections, Intraventricular Insulin Insulin - metabolism Insulin Secretion Intravenous administration Male Mannoheptulose - pharmacology Medical sciences Metabolism Neurons Pancreas Pancreas - metabolism Physiological aspects Rats Rats, Sprague-Dawley Secretion Ventricles (cerebral)
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