Effect of trabectedin on the QT interval in patients with advanced solid tumor malignancies

Purpose The primary objective of this study was to access the potential effects of trabectedin on the QT/QTc interval in patients with locally advanced or metastatic solid tumors. Methods Patients ( n = 75) who had received ≤3 previous lines of chemotherapy and had either relapsed or had progressiv...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2012-02, Vol.69 (2), p.341-350
Hauptverfasser:	Thertulien, R., Manikhas, G. M., Dirix, L. Y., Vermorken, J. B., Park, K., Jain, M. M., Jiao, J. J., Natarajan, J., Parekh, T., Zannikos, P., Staddon, A. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antineoplastic Agents, Alkylating - adverse effects Antineoplastic Agents, Alkylating - pharmacokinetics Antineoplastic Agents, Alkylating - therapeutic use Asthenia - chemically induced Cancer Research Dioxoles - administration & dosage Dioxoles - pharmacokinetics Dioxoles - therapeutic use Electrocardiography - drug effects Female Heart Rate - drug effects Humans Infusions, Intravenous Male Medicine Medicine & Public Health Metabolic Clearance Rate Middle Aged Nausea - chemically induced Neoplasms - drug therapy Neoplasms - pathology Neoplasms - physiopathology Oncology Original Original Article Pharmacology/Toxicology Single-Blind Method Tetrahydroisoquinolines - administration & dosage Tetrahydroisoquinolines - pharmacokinetics Tetrahydroisoquinolines - therapeutic use Treatment Outcome Vomiting - chemically induced Young Adult
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