Developing Central Nervous System and Vulnerability to Platinum Compounds
Comparative studies on the effects of the platinum complexes in use or in clinical trials are carried out in order to discover differences in the neurotoxic potential and the reversibility of neurotoxicity. In this paper, we summarized the current literature on neurotoxicity and chemoresistance of c...
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| Veröffentlicht in: | Chemotherapy Research and Practice 2011-01, Vol.2011 (2011), p.66-79 |
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| container_title | Chemotherapy Research and Practice |
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| creator | Bernocchi, Graziella Bottone, Maria Grazia Piccolini, Valeria Maria Dal Bo, V. Santin, Giada De Pascali, S. A. Migoni, D. Fanizzi, F. P. |
| description | Comparative studies on the effects of the platinum complexes in use or in clinical trials are carried out in order to discover differences in the neurotoxic potential and the reversibility of neurotoxicity. In this paper, we summarized the current literature on neurotoxicity and chemoresistance of cisplatin (cisPt) and discussed our recent efforts on the interference of cisPt and a new platinum compound [Pt(O,O′-acac)(γ-acac)(DMS)] (PtAcacDMS), with high specific reactivity with sulphur ligands instead of nucleobases as cisPt, on some crucial events of rat postnatal cerebellum development. The acute effects of drug treatments on cell proliferation and death in the external granular layer and granule cell migration and the late effects on the dendrite growth of Purkinje cells were evaluated. Together with the demonstrated antineoplastic effectiveness in vitro, compared with cisPt, data suggest a lower neurotoxicity of PtAcacDMS, in spite of its presence in the brain that involves considerations on the blood brain barrier permeability. |
| doi_str_mv | 10.1155/2011/315418 |
| format | Article |
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The acute effects of drug treatments on cell proliferation and death in the external granular layer and granule cell migration and the late effects on the dendrite growth of Purkinje cells were evaluated. Together with the demonstrated antineoplastic effectiveness in vitro, compared with cisPt, data suggest a lower neurotoxicity of PtAcacDMS, in spite of its presence in the brain that involves considerations on the blood brain barrier permeability.</description><identifier>ISSN: 2090-2107</identifier><identifier>EISSN: 2090-2115</identifier><identifier>DOI: 10.1155/2011/315418</identifier><identifier>PMID: 22312552</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Review</subject><ispartof>Chemotherapy Research and Practice, 2011-01, Vol.2011 (2011), p.66-79</ispartof><rights>Copyright © 2011 G. Bernocchi et al.</rights><rights>Copyright © 2011 G. 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The acute effects of drug treatments on cell proliferation and death in the external granular layer and granule cell migration and the late effects on the dendrite growth of Purkinje cells were evaluated. 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| source | PubMed Central Open Access; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Review |
| title | Developing Central Nervous System and Vulnerability to Platinum Compounds |
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