Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

Dendritic cells (DCs) are the most potent APCs. Whereas immature DCs down-regulate T-cell responses to induce/maintain immunologic tolerance, mature DCs promote immunity. To amplify their functions, DCs communicate with neighboring DCs through soluble mediators, cell-to-cell contact, and vesicle exc...

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Veröffentlicht in:	Blood 2012-01, Vol.119 (3), p.756-766
Hauptverfasser:	Montecalvo, Angela, Larregina, Adriana T., Shufesky, William J., Beer Stolz, Donna, Sullivan, Mara L.G., Karlsson, Jenny M., Baty, Catherine J., Gibson, Gregory A., Erdos, Geza, Wang, Zhiliang, Milosevic, Jadranka, Tkacheva, Olga A., Divito, Sherrie J., Jordan, Rick, Lyons-Weiler, James, Watkins, Simon C., Morelli, Adrian E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation Biological and medical sciences Biomarkers - metabolism Cell Communication Cytosol - metabolism Dendritic Cells - cytology Dendritic Cells - metabolism Endosomes - metabolism Exosomes - genetics Exosomes - metabolism Gene Expression Profiling Hematologic and hematopoietic diseases Immunobiology Medical sciences Membrane Fusion Mice MicroRNAs - physiology Oligonucleotide Array Sequence Analysis
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