On the edge: Pharmacological evidence for anxiety-related behavior in zebrafish larvae

► Our high-throughput assay is able to detect anxiety-related behavior in zebrafish. ► Zebrafish larvae naturally avoid a visual moving stimulus and show thigmotaxis. ► Zebrafish larvae treated with diazepam show decreased thigmotaxis. ► Zebrafish larvae treated with fluoxetine show decreased avoida...

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Veröffentlicht in:	Behavioural brain research 2012-03, Vol.228 (1), p.99-106
Hauptverfasser:	Richendrfer, H., Pelkowski, S.D., Colwill, R.M., Creton, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety Anxiety - drug therapy Caffeine - pharmacology Caffeine - therapeutic use Cues Diazepam Diazepam - pharmacology Diazepam - therapeutic use Disease Models, Animal Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods Fluoxetine Fluoxetine - pharmacology Fluoxetine - therapeutic use High-throughput Spatial Behavior - drug effects Swimming Thigmotaxis Zebrafish
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