Retrovirus-transformed erythroleukemia cells induce central nervous system failure in a new syngeneic mouse model of meningeal leukemia

Abstract Lack of suitable mouse models for central nervous system (CNS)-associated leukemias has hindered mechanism-guided development of therapeutics. By transplanting retrovirus-transformed mouse erythroleukemia cells into syngeneic mice, we developed a new animal model of meningeal leukemia assoc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia research 2012-03, Vol.36 (3), p.369-376
Hauptverfasser:	Macpherson, Gordon R, Hanson, Charlotte A, Thompson, Delores M, Perella, Christine M, Cmarik, Joan L, Ruscetti, Sandra K
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal model Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Cell Adhesion Cell Proliferation Central Nervous System Neoplasms - blood supply Central Nervous System Neoplasms - etiology Central Nervous System Neoplasms - pathology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Fibronectins - metabolism Friend SFFV Gene Expression Profiling Hematology, Oncology and Palliative Medicine Integrin alpha5beta1 - metabolism Leukemia, Erythroblastic, Acute - physiopathology Leukemia, Experimental - etiology Leukemia, Experimental - pathology Meningeal leukemia Meningeal Neoplasms - blood supply Meningeal Neoplasms - etiology Meningeal Neoplasms - pathology Mice Mice, Inbred BALB C Murine erythroleukemia cells Oligonucleotide Array Sequence Analysis PU.1 Retroviridae - genetics Vascular Endothelial Growth Factor A - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!