Retrovirus-transformed erythroleukemia cells induce central nervous system failure in a new syngeneic mouse model of meningeal leukemia
Abstract Lack of suitable mouse models for central nervous system (CNS)-associated leukemias has hindered mechanism-guided development of therapeutics. By transplanting retrovirus-transformed mouse erythroleukemia cells into syngeneic mice, we developed a new animal model of meningeal leukemia assoc...
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| Veröffentlicht in: | Leukemia research 2012-03, Vol.36 (3), p.369-376 |
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| creator | Macpherson, Gordon R Hanson, Charlotte A Thompson, Delores M Perella, Christine M Cmarik, Joan L Ruscetti, Sandra K |
| description | Abstract Lack of suitable mouse models for central nervous system (CNS)-associated leukemias has hindered mechanism-guided development of therapeutics. By transplanting retrovirus-transformed mouse erythroleukemia cells into syngeneic mice, we developed a new animal model of meningeal leukemia associated with rapid paralysis. Necropsy revealed massive proliferation of the leukemic cells in the bone marrow (BM) followed by pathological angiogenesis and invasion of the leukemic cells into the meninges of the CNS. Further analysis demonstrated that the erythroleukemia cells secreted high levels of VEGF and preferentially adhered in vitro to fibronectin. This unique animal model for meningeal leukemia should facilitate studies of engraftment and proliferation of leukemic cells in the BM and their invasion of the CNS as well as pre-clinical evaluation of experimental therapeutics for CNS-associated leukemias. |
| doi_str_mv | 10.1016/j.leukres.2011.08.019 |
| format | Article |
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By transplanting retrovirus-transformed mouse erythroleukemia cells into syngeneic mice, we developed a new animal model of meningeal leukemia associated with rapid paralysis. Necropsy revealed massive proliferation of the leukemic cells in the bone marrow (BM) followed by pathological angiogenesis and invasion of the leukemic cells into the meninges of the CNS. Further analysis demonstrated that the erythroleukemia cells secreted high levels of VEGF and preferentially adhered in vitro to fibronectin. This unique animal model for meningeal leukemia should facilitate studies of engraftment and proliferation of leukemic cells in the BM and their invasion of the CNS as well as pre-clinical evaluation of experimental therapeutics for CNS-associated leukemias.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/j.leukres.2011.08.019</identifier><identifier>PMID: 21924771</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Angiogenesis ; Animal model ; Animals ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Blotting, Western ; Cell Adhesion ; Cell Proliferation ; Central Nervous System Neoplasms - blood supply ; Central Nervous System Neoplasms - etiology ; Central Nervous System Neoplasms - pathology ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Fibronectins - metabolism ; Friend SFFV ; Gene Expression Profiling ; Hematology, Oncology and Palliative Medicine ; Integrin alpha5beta1 - metabolism ; Leukemia, Erythroblastic, Acute - physiopathology ; Leukemia, Experimental - etiology ; Leukemia, Experimental - pathology ; Meningeal leukemia ; Meningeal Neoplasms - blood supply ; Meningeal Neoplasms - etiology ; Meningeal Neoplasms - pathology ; Mice ; Mice, Inbred BALB C ; Murine erythroleukemia cells ; Oligonucleotide Array Sequence Analysis ; PU.1 ; Retroviridae - genetics ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Leukemia research, 2012-03, Vol.36 (3), p.369-376</ispartof><rights>2011</rights><rights>Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-4c00916f7a85c76ca4a14a0870db3e4cb6a84b17954ef22e39806321d3ba45023</citedby><cites>FETCH-LOGICAL-c553t-4c00916f7a85c76ca4a14a0870db3e4cb6a84b17954ef22e39806321d3ba45023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S014521261100419X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21924771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macpherson, Gordon R</creatorcontrib><creatorcontrib>Hanson, Charlotte A</creatorcontrib><creatorcontrib>Thompson, Delores M</creatorcontrib><creatorcontrib>Perella, Christine M</creatorcontrib><creatorcontrib>Cmarik, Joan L</creatorcontrib><creatorcontrib>Ruscetti, Sandra K</creatorcontrib><title>Retrovirus-transformed erythroleukemia cells induce central nervous system failure in a new syngeneic mouse model of meningeal leukemia</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Abstract Lack of suitable mouse models for central nervous system (CNS)-associated leukemias has hindered mechanism-guided development of therapeutics. By transplanting retrovirus-transformed mouse erythroleukemia cells into syngeneic mice, we developed a new animal model of meningeal leukemia associated with rapid paralysis. Necropsy revealed massive proliferation of the leukemic cells in the bone marrow (BM) followed by pathological angiogenesis and invasion of the leukemic cells into the meninges of the CNS. Further analysis demonstrated that the erythroleukemia cells secreted high levels of VEGF and preferentially adhered in vitro to fibronectin. This unique animal model for meningeal leukemia should facilitate studies of engraftment and proliferation of leukemic cells in the BM and their invasion of the CNS as well as pre-clinical evaluation of experimental therapeutics for CNS-associated leukemias.</description><subject>Angiogenesis</subject><subject>Animal model</subject><subject>Animals</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Blotting, Western</subject><subject>Cell Adhesion</subject><subject>Cell Proliferation</subject><subject>Central Nervous System Neoplasms - blood supply</subject><subject>Central Nervous System Neoplasms - etiology</subject><subject>Central Nervous System Neoplasms - pathology</subject><subject>Disease Models, Animal</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fibronectins - metabolism</subject><subject>Friend SFFV</subject><subject>Gene Expression Profiling</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Integrin alpha5beta1 - metabolism</subject><subject>Leukemia, Erythroblastic, Acute - physiopathology</subject><subject>Leukemia, Experimental - etiology</subject><subject>Leukemia, Experimental - pathology</subject><subject>Meningeal leukemia</subject><subject>Meningeal Neoplasms - blood supply</subject><subject>Meningeal Neoplasms - etiology</subject><subject>Meningeal Neoplasms - pathology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Murine erythroleukemia cells</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>PU.1</subject><subject>Retroviridae - genetics</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUttu1DAQjRCILoVPAOWNpywzvsTJSxGqykWqhMRF4s3yOpPW28QudrJov4DfxtFuK-ClL7bsOXPOzJwpipcIawSs32zXA803kdKaAeIamjVg-6hYYaN4JRsuHxcrQCErhqw-KZ6ltAUA2WL7tDhh2DKhFK6K319oimHn4pyqKRqf-hBH6kqK--k6hkWDRmdKS8OQSue72VJ--IwdSk9xF-ZUpn2aaCx744Y5UkaVJsd-5X9_RZ6cLccMo3x2NJShL0fyLocyxZ3A8-JJb4ZEL473afH9_cW384_V5ecPn87fXVZWSj5VwgK0WPfKNNKq2hphUBhoFHQbTsJuatOIDapWCuoZI942UHOGHd8YIYHx0-LswHs7b3Kfx070bXSjiXsdjNP_Rry71ldhpzmrhaoxE7w-EsTwc6Y06dGlZTrGU25StwyarCPUw0hUUgnOl6LkAWljSClSf18Pgl7c1lt9dFsvbmtodHY75736u5n7rDt7M-DtAUB5pDtHUSfryFvqXCQ76S64ByXO_mOwg_POmuGG9pS2YY4--6VRJ6ZBf11Wbtk4RACB7Q_-B2zE14I</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Macpherson, Gordon R</creator><creator>Hanson, Charlotte A</creator><creator>Thompson, Delores M</creator><creator>Perella, Christine M</creator><creator>Cmarik, Joan L</creator><creator>Ruscetti, Sandra K</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20120301</creationdate><title>Retrovirus-transformed erythroleukemia cells induce central nervous system failure in a new syngeneic mouse model of meningeal leukemia</title><author>Macpherson, Gordon R ; Hanson, Charlotte A ; Thompson, Delores M ; Perella, Christine M ; Cmarik, Joan L ; Ruscetti, Sandra K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-4c00916f7a85c76ca4a14a0870db3e4cb6a84b17954ef22e39806321d3ba45023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Angiogenesis</topic><topic>Animal model</topic><topic>Animals</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Blotting, Western</topic><topic>Cell Adhesion</topic><topic>Cell Proliferation</topic><topic>Central Nervous System Neoplasms - blood supply</topic><topic>Central Nervous System Neoplasms - etiology</topic><topic>Central Nervous System Neoplasms - pathology</topic><topic>Disease Models, Animal</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fibronectins - metabolism</topic><topic>Friend SFFV</topic><topic>Gene Expression Profiling</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Integrin alpha5beta1 - metabolism</topic><topic>Leukemia, Erythroblastic, Acute - physiopathology</topic><topic>Leukemia, Experimental - etiology</topic><topic>Leukemia, Experimental - pathology</topic><topic>Meningeal leukemia</topic><topic>Meningeal Neoplasms - blood supply</topic><topic>Meningeal Neoplasms - etiology</topic><topic>Meningeal Neoplasms - pathology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Murine erythroleukemia cells</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>PU.1</topic><topic>Retroviridae - genetics</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Macpherson, Gordon R</creatorcontrib><creatorcontrib>Hanson, Charlotte A</creatorcontrib><creatorcontrib>Thompson, Delores M</creatorcontrib><creatorcontrib>Perella, Christine M</creatorcontrib><creatorcontrib>Cmarik, Joan L</creatorcontrib><creatorcontrib>Ruscetti, Sandra K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Macpherson, Gordon R</au><au>Hanson, Charlotte A</au><au>Thompson, Delores M</au><au>Perella, Christine M</au><au>Cmarik, Joan L</au><au>Ruscetti, Sandra K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrovirus-transformed erythroleukemia cells induce central nervous system failure in a new syngeneic mouse model of meningeal leukemia</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>36</volume><issue>3</issue><spage>369</spage><epage>376</epage><pages>369-376</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><abstract>Abstract Lack of suitable mouse models for central nervous system (CNS)-associated leukemias has hindered mechanism-guided development of therapeutics. By transplanting retrovirus-transformed mouse erythroleukemia cells into syngeneic mice, we developed a new animal model of meningeal leukemia associated with rapid paralysis. Necropsy revealed massive proliferation of the leukemic cells in the bone marrow (BM) followed by pathological angiogenesis and invasion of the leukemic cells into the meninges of the CNS. Further analysis demonstrated that the erythroleukemia cells secreted high levels of VEGF and preferentially adhered in vitro to fibronectin. This unique animal model for meningeal leukemia should facilitate studies of engraftment and proliferation of leukemic cells in the BM and their invasion of the CNS as well as pre-clinical evaluation of experimental therapeutics for CNS-associated leukemias.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>21924771</pmid><doi>10.1016/j.leukres.2011.08.019</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Leukemia research, 2012-03, Vol.36 (3), p.369-376 |
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| subjects | Angiogenesis Animal model Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Cell Adhesion Cell Proliferation Central Nervous System Neoplasms - blood supply Central Nervous System Neoplasms - etiology Central Nervous System Neoplasms - pathology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Fibronectins - metabolism Friend SFFV Gene Expression Profiling Hematology, Oncology and Palliative Medicine Integrin alpha5beta1 - metabolism Leukemia, Erythroblastic, Acute - physiopathology Leukemia, Experimental - etiology Leukemia, Experimental - pathology Meningeal leukemia Meningeal Neoplasms - blood supply Meningeal Neoplasms - etiology Meningeal Neoplasms - pathology Mice Mice, Inbred BALB C Murine erythroleukemia cells Oligonucleotide Array Sequence Analysis PU.1 Retroviridae - genetics Vascular Endothelial Growth Factor A - metabolism |
| title | Retrovirus-transformed erythroleukemia cells induce central nervous system failure in a new syngeneic mouse model of meningeal leukemia |
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