Oxidative modification of rat sulfotransferase 1A1 activity in hepatic tissue slices correlates with effects on the purified enzyme

Mammalian cytosolic sulfotransferases (SULTs) catalyze the sulfation of xenobiotics as well as numerous endogenous molecules. The major aryl (phenol) SULT in rat liver, rSULT1A1, has been used extensively as a model enzyme for understanding the catalytic function of SULTs. Previous studies showed th...

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Veröffentlicht in:	Drug metabolism and disposition 2012-02, Vol.40 (2), p.298-303
Hauptverfasser:	Dammanahalli, Jagadeesha K, Duffel, Michael W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arylsulfotransferase - chemistry Arylsulfotransferase - genetics Arylsulfotransferase - metabolism Cell Survival - drug effects Dimethylformamide - analogs & derivatives Dimethylformamide - pharmacology Glutathione - metabolism In Vitro Techniques Kinetics Liver - drug effects Liver - enzymology Liver - metabolism Male Osmolar Concentration Oxidants - pharmacology Oxidation-Reduction Oxidative Stress Rats Rats, Sprague-Dawley Recombinant Proteins - agonists Recombinant Proteins - chemistry Recombinant Proteins - metabolism tert-Butylhydroperoxide - pharmacology Umbelliferones - metabolism
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