Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

In obesity, anorectic responses to leptin are diminished, giving rise to the concept of “leptin resistance.” Increased expression of protein tyrosine phosphatase 1B (PTP1B) has been associated with the attenuation of leptin signaling and development of cellular leptin resistance. Here we report that...

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Veröffentlicht in:	Cell metabolism 2011-11, Vol.14 (5), p.684-699
Hauptverfasser:	Loh, Kim, Fukushima, Atsushi, Zhang, Xinmei, Galic, Sandra, Briggs, Dana, Enriori, Pablo J., Simonds, Stephanie, Wiede, Florian, Reichenbach, Alexander, Hauser, Christine, Sims, Natalie A., Bence, Kendra K., Zhang, Sheng, Zhang, Zhong-Yin, Kahn, Barbara B., Neel, Benjamin G., Andrews, Zane B., Cowley, Michael A., Tiganis, Tony
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - analysis Body Composition - drug effects Diet, High-Fat Enzyme Inhibitors - pharmacology Female Gene Expression Hypothalamus - cytology Hypothalamus - metabolism Infusions, Intraventricular Insulin - blood Leptin - metabolism Male Mice Mice, Transgenic Neurons - cytology Neurons - metabolism Obesity - genetics Obesity - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 1 - deficiency Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 2 - antagonists & inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 2 - deficiency Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics Receptors, Leptin - metabolism Signal Transduction Tissue Culture Techniques
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