IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner

IL-13 is a central mediator of airway hyperresponsiveness and mucus expression, both hallmarks of asthma. IL-13 is found in the sputum of patients with asthma; therefore, IL-13 is an attractive drug target for treating asthma. We have shown previously that IL-13 inhibits Th17 cell production of IL-1...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2012-02, Vol.188 (3), p.1027-1035
Hauptverfasser:	Newcomb, Dawn C, Boswell, Madison G, Huckabee, Matthew M, Goleniewska, Kasia, Dulek, Daniel E, Reiss, Sara, Lukacs, Nicholas W, Kolls, Jay K, Peebles, Jr, R Stokes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement Interleukin-10 - physiology Interleukin-13 - physiology Interleukin-17 - secretion Lung - immunology Lung - metabolism Mice Mice, Knockout Neutrophil Infiltration - immunology Pneumonia - immunology Pneumonia - pathology Pneumonia - virology Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Th17 Cells - secretion
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!