Pneumocystis S-adenosylmethionine transport: a potential drug target

Pneumocystis pneumonia (PCP) is a life-threatening condition in immunosuppressed patients. Current treatments are inadequate, and new drug leads are needed. This fungus depends on its host for S-adenosylmethionine (AdoMet), a critical metabolic intermediate ordinarily synthesized by individual cells...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of respiratory cell and molecular biology 2011-12, Vol.45 (6), p.1142-1146
Hauptverfasser:	Perez-Leal, Oscar, Moncada, Camilo, Clarkson, Allen B, Merali, Salim
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Animals Antifungal Agents - pharmacology Biological Transport - drug effects Drug Delivery Systems Fungal Proteins - genetics Fungal Proteins - metabolism Humans Methionine Adenosyltransferase - genetics Methionine Adenosyltransferase - metabolism Pneumocystis carinii - enzymology Pneumocystis carinii - genetics Pneumocystis carinii - growth & development Pneumonia, Pneumocystis - drug therapy Pneumonia, Pneumocystis - enzymology Recombinant Proteins - genetics Recombinant Proteins - metabolism S-Adenosylmethionine - genetics S-Adenosylmethionine - metabolism Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!