The complete nucleotide sequence of the I-Eαd immune response gene

The complete nucleotide sequence of the I-Eαd immune response gene

We have isolated and sequenced the complete muring I-Ea immune response gene of the H-2a haplotype. The I-Ea gene consists of 5300 basepairs and is organized into five or possibly six exons that correspond to different domains of the a chain. The amino acid sequence deduced from the I-Ea gene shows...

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Veröffentlicht in:Nucleic acids research 1983-08, Vol.11 (15), p.5055-5071
Hauptverfasser: Hyldig-Nielsen, Jens Jörgen, schenning, Lena, Hammerling, Ulf, Widmark, Eva, Heldin, Eva, Lind, Peter, Servenius, Bo, Lund, Torben, Flavel, Richard, Lee, Janet S., Trowsdale, John, Schreier, Peter H., Zablitzky, Fred, Larhammar, Dan, Peterson, Per A., Rask, Lars
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA Restriction Enzymes
Genes
Humans
Major Histocompatibility Complex
Mice
Plasmids
Species Specificity
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Zusammenfassung:We have isolated and sequenced the complete muring I-Ea immune response gene of the H-2a haplotype. The I-Ea gene consists of 5300 basepairs and is organized into five or possibly six exons that correspond to different domains of the a chain. The amino acid sequence deduced from the I-Ea gene shows 75% homology to its human counterpart, the HLA-DR a chain. The absence of I-E antigen in H-2a mice is due to lack of Ea chain synthesis. We show here that this defect is caused by a deletion in the 5' end of the I-Eabgene.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/11.15.5055