Genomic and phenotypic analysis of BRCA2 mutated breast cancers reveals co-occurring changes linked to progression

Inherited mutations in the BRCA2 gene greatly increase the risk of developing breast cancer. Consistent with an important role for BRCA2 in error-free DNA repair, complex genomic changes are frequently observed in tumors derived from BRCA2 mutation carriers. Here, we explore the impact of DNA copy-n...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Breast cancer research : BCR 2011-09, Vol.13 (5), p.R95-R95
Hauptverfasser:	Stefansson, Olafur A, Jonasson, Jon G, Olafsdottir, Kristrun, Bjarnason, Hordur, Th Johannsson, Oskar, Bodvarsdottir, Sigridur K, Valgeirsdottir, Sigridur, Eyfjord, Jorunn E
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA2 Protein - genetics Breast cancer Breast Neoplasms - etiology Breast Neoplasms - genetics Breast Neoplasms - pathology Chromosome Deletion Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 6 Comparative Genomic Hybridization Development and progression Disease Progression Female Gene Dosage Gene mutations Genes, p16 Humans Ki-67 Antigen - metabolism Mutation Phenotype Physiological aspects Ploidies
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!