Inhibitor of Differentiation-3 Mediates High Fat Diet-Induced Visceral Fat Expansion

OBJECTIVE—Inhibitor of differentiation-3 (Id3) has been implicated in promoting angiogenesis, a key determinant of high-fat diet (HFD)-induced visceral adiposity. Yet the role of Id3 in HFD-induced angiogenesis and visceral adipose expansion is unknown. METHODS AND RESULTS—Id3 mice demonstrated a si...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2012-02, Vol.32 (2), p.317-324
Hauptverfasser:	Cutchins, Alexis, Harmon, Daniel B, Kirby, Jennifer L, Doran, Amanda C, Oldham, Stephanie N, Skaflen, Marcus, Klibanov, Alexander L, Meller, Nahum, Keller, Susanna R, Garmey, James, McNamara, Coleen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - pathology Adiposity - physiology Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Volume - physiology Cardiology. Vascular system Dietary Fats - pharmacology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug toxicity and drugs side effects treatment Inhibitor of Differentiation Proteins - deficiency Inhibitor of Differentiation Proteins - genetics Inhibitor of Differentiation Proteins - metabolism Intra-Abdominal Fat - blood supply Intra-Abdominal Fat - metabolism Intra-Abdominal Fat - pathology Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Models, Animal Neovascularization, Physiologic - physiology Pharmacology. Drug treatments Signal Transduction - physiology Toxicity: blood Vascular Endothelial Growth Factor A - metabolism
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