Two Zebrafish Alcohol Dehydrogenases Share Common Ancestry with Mammalian Class I, II, IV, and V Alcohol Dehydrogenase Genes but Have Distinct Functional Characteristics

Ethanol is teratogenic to many vertebrates. We are utilizing zebrafish as a model system to determine whether there is an association between ethanol metabolism and ethanol-mediated developmental toxicity. Here we report the isolation and characterization of two cDNAs encoding zebrafish alcohol dehy...

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Veröffentlicht in:	The Journal of biological chemistry 2004-09, Vol.279 (37), p.38303-38312
Hauptverfasser:	Reimers, Mark J., Hahn, Mark E., Tanguay, Robert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Dehydrogenase - chemistry Alcohol Dehydrogenase - genetics Amino Acid Sequence Animals Binding, Competitive Cell Line Chromosome Mapping Conserved Sequence Danio rerio DNA, Complementary - metabolism Ethanol - pharmacology Freshwater Glutathione - analogs & derivatives Glutathione - chemistry Humans Insecta Kinetics Marine Mice Molecular Sequence Data Open Reading Frames Phylogeny Rats Recombinant Proteins - chemistry RNA, Messenger - metabolism Sequence Homology, Amino Acid Species Specificity Time Factors Tissue Distribution Zebrafish
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