Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells

Objective Resveratrol, trans-3, 4′, 5,-trihydroxystilbene, suppresses multiple myeloma (MM). The endoplasmic reticulum (ER) stress response component inositol-requiring enzyme 1α (IRE1α)/X-box binding protein 1 (XBP1) axis is essential for MM pathogenesis. We investigated the molecular action of res...

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Veröffentlicht in:	Experimental hematology 2011-10, Vol.39 (10), p.999-1006
Hauptverfasser:	Wang, Feng-Ming, Galson, Deborah L, Roodman, G. David, Ouyang, Hongjiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Apoptosis - drug effects Cell Line, Tumor - drug effects Cell Line, Tumor - metabolism Chromatin Immunoprecipitation DNA, Neoplasm - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - physiology Drug Screening Assays, Antitumor Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoribonucleases - physiology Gene Expression Regulation, Neoplastic - drug effects Hematology, Oncology and Palliative Medicine Humans Multiple Myeloma - pathology Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - physiology Phosphorylation - drug effects Protein Binding - drug effects Protein Processing, Post-Translational - drug effects Protein-Serine-Threonine Kinases - physiology Regulatory Factor X Transcription Factors RNA Splicing - drug effects Signal Transduction Sirtuin 1 - metabolism Stilbenes - pharmacology Transcription Factors - antagonists & inhibitors Transcription Factors - physiology Transcription, Genetic - drug effects Unfolded Protein Response - drug effects X-Box Binding Protein 1
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