Cdk1 promotes kinetochore bi-orientation and regulates Cdc20 expression during recovery from spindle checkpoint arrest

The spindle assembly checkpoint (SAC), an evolutionarily conserved surveillance pathway, prevents chromosome segregation in response to conditions that disrupt the kinetochore‐microtubule attachment. Removal of the checkpoint‐activating stimulus initiates recovery during which spindle integrity is r...

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Veröffentlicht in:	The EMBO journal 2012-01, Vol.31 (2), p.403-416
Hauptverfasser:	Liang, Hongqing, Lim, Hong Hwa, Venkitaraman, Ashok, Surana, Uttam
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase - physiology Anaphase-Promoting Complex-Cyclosome CDC2 Protein Kinase - antagonists & inhibitors CDC2 Protein Kinase - physiology Cdc20 Proteins cell cycle Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - genetics Cell division checkpoint EMBO06 Gene expression Gene Expression Regulation, Fungal Kinetochores - physiology Kinetochores - ultrastructure M Phase Cell Cycle Checkpoints - physiology Microtubules - physiology Microtubules - ultrastructure mitosis Molecular biology Nocodazole - pharmacology Pharmacology Pyrazoles - pharmacology Pyrimidines - pharmacology recovery Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - biosynthesis Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - physiology Spindle Apparatus - drug effects Spindle Apparatus - physiology Spindle Apparatus - ultrastructure Ubiquitin-Protein Ligase Complexes - physiology Yeast Yeasts
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