Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells

HERG (human ether-à-go-go-related gene) K + currents fulfill important ionic functions in cardiac and other excitable cells. In addition, HERG channels influence cell growth and migration in various types of tumor cells. The mechanisms underlying these functions are still not resolved. Here, we inve...

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Veröffentlicht in:	Pflügers Archiv 2012-02, Vol.463 (2), p.365-376
Hauptverfasser:	Glassmeier, Günter, Hempel, Kathrin, Wulfsen, Iris, Bauer, Christiane K., Schumacher, Udo, Schwarz, Jürgen R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cell Biology Cell Line, Tumor Cell Proliferation - drug effects Ether-A-Go-Go Potassium Channels - antagonists & inhibitors Ether-A-Go-Go Potassium Channels - drug effects Ether-A-Go-Go Potassium Channels - metabolism Human Physiology Humans Lung Neoplasms - metabolism Lung Neoplasms - pathology Membrane Potentials - drug effects Membrane Potentials - physiology Molecular Medicine Neurosciences Piperidines - pharmacology Pyridines - pharmacology Receptors RNA, Small Interfering - pharmacology Signaling and Cell Physiology Small Cell Lung Carcinoma - metabolism Small Cell Lung Carcinoma - pathology
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