Decreased dopamine activity predicts relapse in methamphetamine abusers

Studies in methamphetamine (METH) abusers showed that the decreases in brain dopamine (DA) function might recover with protracted detoxification. However, the extent to which striatal DA function in METH predicts recovery has not been evaluated. Here we assessed whether striatal DA activity in METH...

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Veröffentlicht in:	Molecular psychiatry 2012-09, Vol.17 (9), p.918-925
Hauptverfasser:	Wang, G J, Smith, L, Volkow, N D, Telang, F, Logan, J, Tomasi, D, Wong, C T, Hoffman, W, Jayne, M, Alia-Klein, N, Thanos, P, Fowler, J S
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/340 631/92/436/1729 692/53/2423 Abstinence Adult Amphetamine abuse Amphetamine-Related Disorders - diagnostic imaging Amphetamine-Related Disorders - metabolism Amphetamines Behavioral Sciences Biological and medical sciences Biological Psychology Brain Carbon Radioisotopes Case-Control Studies Caudate-putamen Clinical outcomes Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Detoxification Diagnosis Diseases Dopamine Dopamine - metabolism Dopamine D2 receptors Dopamine receptors Drugs Female Humans Male Medical sciences Medicine Medicine & Public Health Methamphetamine Methamphetamine - adverse effects Methylphenidate Methylphenidate - pharmacology Monkeys & apes Neostriatum Neuropharmacology Neurosciences original-article Pharmacology. Drug treatments Pharmacotherapy Physiological aspects Positron emission tomography Positron-Emission Tomography - methods Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Putamen Raclopride Receptors, Dopamine D2 - metabolism Recurrence Relapse Substance abuse treatment Time Factors Tomography
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