Nuclear Ago2/HSP60 contributes to broad spectrum of hATSCs function via Oct4 regulation

Argonaute2 (Ago2) plays a fundamental role in microRNA-mediated gene regulation through its intrinsic endonuclease activity. In this study we demonstrate the novel functions and molecular mechanisms by which nuclear Ago2 directly regulates HSP (heat shock protein) 60 expression and stem cell self-re...

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Veröffentlicht in:	Antioxidants & redox signaling 2012-03, Vol.16 (5), p.383-399
Hauptverfasser:	Jang, Jin Hwa, Jung, Jin Sun, Choi, Jee In, Kang, Soo Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Argonaute Proteins - genetics Argonaute Proteins - metabolism Cell Death Cell Differentiation Cell Nucleus - genetics Cell Nucleus - metabolism Cell Proliferation Cell Survival Chaperonin 60 - genetics Chaperonin 60 - metabolism Humans Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Original Research Communications Reactive Oxygen Species - metabolism Stem Cells - cytology Stem Cells - metabolism
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