Neuroglobin Is an Endogenous Neuroprotectant for Retinal Ganglion Cells against Glaucomatous Damage

Neuroglobin (NGB), a newly discovered member of the globin superfamily, may regulate neuronal survival under hypoxia or oxidative stress. Although NGB is greatly expressed in retinal neurons, the biological functions of NGB in retinal diseases remain largely unknown. We investigated the role of NGB...

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Veröffentlicht in:	The American journal of pathology 2011-12, Vol.179 (6), p.2788-2797
Hauptverfasser:	Wei, Xin, Yu, Zhanyang, Cho, Kin-Sang, Chen, Huihui, Malik, Muhammad Taimur A, Chen, Xiaoming, Lo, Eng H, Wang, Xiaoying, Chen, Dong F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Glaucoma - metabolism Glaucoma - physiopathology Globins - metabolism Globins - physiology Intraocular Pressure - physiology Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Mitochondrial Diseases - metabolism Mitochondrial Diseases - physiopathology Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Oxidative Stress Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Reactive Oxygen Species - metabolism Regular Retinal Ganglion Cells - physiology Superoxides - metabolism
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