Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism

The authors have developed a new inhibitor of the enzyme that degrades the endocannabinoid anandamide. This new drug does not cross the blood-brain barrier. It elevates peripheral anandamide only, which, acting on peripheral CB1 receptors, attenuates pain responses in rodents. Peripheral cannabinoid...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2010-10, Vol.13 (10), p.1265-1270
Hauptverfasser:	Clapper, Jason R, Moreno-Sanz, Guillermo, Russo, Roberto, Guijarro, Ana, Vacondio, Federica, Duranti, Andrea, Tontini, Andrea, Sanchini, Silvano, Sciolino, Natale R, Spradley, Jessica M, Hohmann, Andrea G, Calignano, Antonio, Mor, Marco, Tarzia, Giorgio, Piomelli, Daniele
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2620/410 631/378/2649/1723 Amidohydrolases - deficiency Amidohydrolases - metabolism Analgesics Anandamide Animal Genetics and Genomics Animals Arachidonic Acids - metabolism Arachidonic Acids - therapeutic use Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cannabinoid Receptor Modulators - antagonists & inhibitors Cannabinoid Receptor Modulators - metabolism Cannabinoid Receptor Modulators - therapeutic use Cannabinoids Cannabinoids - pharmacology Cannabinoids - therapeutic use Care and treatment Carrageenan Chromatography, Liquid - methods Disease Models, Animal Dosage and administration Drug Administration Routes Drug Administration Schedule Drug dosages Endocannabinoids Enzyme Inhibitors Enzymes Escape Reaction - drug effects Ethylene Glycols - metabolism Evoked potentials (Electrophysiology) Feeding Behavior - drug effects Formaldehyde Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Hyperalgesia - drug therapy Hyperalgesia - genetics Indoles - therapeutic use Inflammation Liver Male Mass Spectrometry - methods Methods Mice Mice, Inbred C57BL Mice, Knockout Monoacylglycerol Lipases - metabolism Motor Activity - drug effects Narcotics Neurobiology Neurosciences Oncogene Proteins v-fos - metabolism Pain Pain - chemically induced Pain - genetics Pain - pathology Pain - prevention & control Pain Measurement - drug effects Pain Threshold - drug effects Peripheral Nervous System Diseases Permeability Physiological aspects Piperidines - therapeutic use Polyunsaturated Alkamides - metabolism Polyunsaturated Alkamides - therapeutic use PPAR alpha - deficiency Pyrazoles - therapeutic use Rats Rats, Sprague-Dawley Sciatica - drug therapy Spinal cord Spinal Cord - metabolism Statistics, Nonparametric Time Factors Tissue Distribution - drug effects Tritium
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!