Connexin Gene Transfer Preserves Conduction Velocity and Prevents Atrial Fibrillation

Several lines of evidence have suggested that maintenance of atrial fibrillation (AF) depends on reentrant mechanisms. Maintenance of reentry necessitates a sufficiently short refractory period and/or delayed conduction, and AF has been associated with both alterations. Fibrosis, cellular dysfunctio...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2012-01, Vol.125 (2), p.216-225
Hauptverfasser:	IGARASHI, Tomonori, FINET, J. Emanuel, TAKEUCHI, Ayano, FUJINO, Yoshihisa, STROM, Maria, GREENER, Ian D, ROSENBAUM, David S, DONAHUE, J. Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrial Fibrillation - prevention & control Atrial Fibrillation - therapy Biological and medical sciences Blood and lymphatic vessels Cardiac Pacing, Artificial Cardiology. Vascular system Connexin 43 - genetics Connexin 43 - physiology Connexins - genetics Connexins - physiology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Gap Junction alpha-5 Protein Gene Transfer Techniques Genetic Therapy Heart Conduction System Medical sciences Neurosurgery Skull, brain, vascular surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Swine Treatment Outcome
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